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The PROVE IT-TIMI trial compared mg/day pravastatin with mg/day atorvastatin.
Like other statins, atorvastatin is a member of the enzyme decreases de novo cholesterol synthesis, increasing expression of low-density lipoprotein receptors (LDL receptors) on hepatocytes. Atorvastatin inhibits the rate-determining enzyme located in hepatic tissue that produces mevalonate, a small molecule used in the blood.
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